David Ortiz clubbed a grand slam in the eighth and Jarrod Saltalamacchia belted the game-winning run in the ninth as Boston rallied to beat Detroit 6-5 in game two of the ALCS.
Ortiz's two-out, game-tying grand slam in the bottom of the eighth inning brought the Red Sox to life after the Tigers had seized a 5-1 lead.
Saltalamacchia's walkoff single in front of a crowd of 38,029 at Fenway Park clinched the victory for Boston, who evened the series at one game apiece.
The American League series now shifts to Detroit for game three on Tuesday. The winner of this series will face either the Los Angeles Dodgers or the St. Louis Cardinals for the Major League Baseball championship.
Saltalamacchia belted an opposite-field single past a drawn-in Tigers' infield to score the deciding run.
Boston starting pitcher Clay Buchholz struck out six, but also allowed five runs on eight hits in just over five innings of work.
Boston and Detroit have been playing one another since 1901, but this marks the first time they have met in the MLB's semi-finals.
The Tigers were 4-3 against the Red Sox in the regular season, winning three of four at Comerica Park in June and dropping two of three at Fenway Park in September.
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