Robert Griffin III dislocated his left ankle and DeSean Jackson sprained his left shoulder in the first quarter, before Kirk Cousins stepped to complete 22 of 33 passes for 250 yards and a pair of touchdowns on Sunday in the Washington Redskins' 41-10 romp past Jacksonville Jaguars.
Griffin was carted to the locker room with his leg in a splint and could be out for two months. He will undergo X-rays to determine if the ankle is broken.
Cousins subbed for Griffin and completed his first 12 passes. Ryan Kerrigan had four of the Redskins' 10 sacks, and Washington's defence didn't allow Jacksonville (0-2) past midfield until the final two minutes of the first half.
At San Diego, Antonio Gates had three touchdown catches as the Chargers controlled the tempo to keep Seattle's offence off the field in a 30-21 win over the Seahawks.
Gates' 21-yard catch late in the third quarter was epic, as the star tight end split two defenders and extended for Philip Rivers' pass, reaching out with his left hand to gather it in. Flat on his back, he held up the ball to show the officials he made the catch that gave San Diego a 27-14 lead.
Chicago's Jay Cutler passed for three fourth-quarter touchdowns as the Bears downed the San Francisco 49ers 29-20.
The Cleveland Browns edged the New Orleans Saints 26-24 after Billy Cundiff kicked a 29-yard field goal with three seconds left. The win ended the Browns' nine-game losing streak in home openers and gave rookie coach Mike Pettine his first NFL win.
Aaron Rodgers threw for three touchdowns and Jordy Nelson had a career-high 209 yards receiving as the Green Bay Packers rallied from an 18-point deficit to beat the New York Jets 31-24.
New York appeared to tie it with five minutes left on a 37-yard catch by Jeremy Kerley on fourth down - but it was negated because the Jets (1-1) called a timeout from the sideline just before the snap. The Packers (1-1) held on from there to avoid their first 0-2 start since 2006.
In other games, Terrance Knighton batted away Alex Smith's fourth-and-goal pass to Dwayne Bowe with 15 seconds left as the Denver Broncos defeated the Kansas City Chiefs 24-17, the Carolina Panthers downed the Detroit Lions 24-7, the Dallas Cowboys beat the Tennessee Titans 26-10 and the Houston Texans downed the Oakland Raiders 30-14.
The Cincinnati Bengals ran past the Atlanta Falcons 24-10, the Buffalos downed the Miami Dolphins 29-10, the St. Louis Rams edged the Tampa Bay Buccaneers 19-17 and the Arizona Cardinals were 25-14 winners over the New York Giants.
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