The Australian-born media tycoon hit back at Republican presidential hopeful Donald Trump for his comments on Mexican immigrants, saying Mexican immigrants are less likely to commit crimes than American-born citizens.
On Twitter, Mr Murdoch wrote:
He declared the Mexico border city of El Paso - where Hispanics account for 81 per cent of the population - as the "safest city in the US", saying Trump had got it "wrong".
Donald Trump has seen a rise in popularity in several Republican primary polls.
Mr Trump began his campaign last month. In speech announcing his candidacy for the Republican party he said undocumented immigrants from Mexico were "people that have lots of problems, and they're bringing those problems with us".
"They're bringing drugs. They're bringing crime. They're rapists. And some, I assume, are good people."
Mr Murdoch's media empire, including Fox News as well as the Wall Street Journal and New York Post, has been influential within the US Republican Party.
His support is considered an important element to running a successful presidential campaign.
A report by the Republican party following its defeat in 2012, recommended it make inroads with the 25 million Hispanic voters in the US before 2016.
Latino voters played a major role in the election of then, Democrat candidate, and current President of the United States, Barack Obama.
Mr Trump's anti-immigration comments have also been fodder for the party's major political opponents.
Democrat presidential candidate, Hillary Clinton, tweeting, 'For Mr Trump, I have one word.. enough'.
"Para el Señor Trump, solo tengo una palabra." pic.twitter.com/7CJnin3aGh
— Hillary Clinton (@HillaryClinton) July 13, 2015
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