A stand alone Indigenous college at the University of South Australia will close by the end of the year.
Programs offered by Adelaide's David Unaipon College for Indigenous Education and Research will be absorbed by other UniSA campuses.
Vice Chancellor Professor David Lloyd says there is no longer any point in having a separate Indigenous campus.
"Models established in the 1970s and 1980s that relied on a single Indigenous school to operate as a supportive entry point for Indigenous students no longer reflect the way ... students approach education or the way they see themselves," he said on Tuesday.
UniSA will also create an Indigenous pro-vice chancellor position.
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The changes come after a government-commissioned review published in 2012 recommended a shake-up of the way Indigenous education is delivered.
Prof Lloyd said no staff would lose their jobs as part of the campus closure.
He also said the move was part of UniSA's plan to become Australia's leading educator for Aboriginal students.
