Sanchez was not in the squad for Arsenal's third round exit to Nottingham Forest earlier this month, so therefore avoided being cup-tied for United.
He will be joined in attack by Marcus Rashford who takes the place of Belgian striker Romelu Lukaku, while Sergio Romero also gets a rare start in goal taking the place of David de Gea.
(Reporting by Christian Radnedge,; Editing by Pritha Sarkar)
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