The club, who were promoted to Serie A at the end of the 2015-2016 campaign, said the decision was made "reluctantly" and in the hope that it will spark an improvement in performances.
Pescara, who host 16th-placed Genoa on Sunday, said that they hope to decide on a new coach shortly.
(Reporting by Silvia Recchimuzzi in Gdynia; Editing by Toby Davis)
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