In the 58th minute Reina misread a curling cross by Taras Stepanenko from the left that connected with Ferreyra, who tapped in the ball for Shakhtar's second goal.
Napoli failed to capitalise on their chances after Polish striker Arkadiusz Milik scored in the 72nd minute from a penalty awarded for a foul on Dries Mertens.
(Writing by Gabrielle Tétrault-Farber; Editing by Clare Fallon)
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