Prop Adriaanse, who played his only test against France in November, replaces Tendai Mtawarira after the loose-head forward sustained a neck injury in last Saturday's 31-30 victory over Wales in Nelspruit.
Uncapped lock Lewies comes in for Flip van der Merwe who injured knee ligaments late in the same game.
"Lourens has been with us before and I'm sure he will slot back in easily," coach Heyneke Meyer said in a news release on Monday.
"Stephan was part of our training squad in Durban at the end of last month. He has been very good in Super Rugby this year and deserves this opportunity."
The Springboks could also be without loose forward Willem Alberts because of concussion.
His progress will be monitored and a final decision on his availability made later in the week.
(Reporting by Nick Said; editing by Tony Jimenez; nick.said@thomsonreuters.com +27832722948 Messaging nick.said.thomsonreuters.com@reuters.net; To sign up for our Global Sports Forum chatroom, click on https://forms.thomsonreuters.com/global_sports_forum)
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