The 31-year-old, twice a runner-up at Roland Garros, has not played an ATP World Tour event since 2011 due to mononucleosis, an energy-sapping viral illness.
"Thank you so much for all your kind words. So sad I won't play professional tennis again, but reading all your msgs makes me feel a lot better," Soderling said on his Twitter account.
Soderling spent 10 years on the Tour and rose to world number four.
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In 2009 he ended Nadal's domination in Paris with a stunning victory, only to lose to Roger Federer in the final -- Federer's only title at the claycourt grand slam.
(This version of the story corrects ranking in paragraph four)
(Reporting by Martyn Herman; editing by Sudipto Ganguly)
