In a repeat of the 2010 World Cup final, Spain took a 27th- minute lead through a Xabi Alonso penalty after Brazilian-born striker Diego Costa went down in the box under a challenge from Dutchman Stefan de Vrij.
Van Persie equalised brilliantly in the 44th minute, connecting with a long searching pass by left back Daley Blind.
(Reporting by Neil Maidment, editing by Ed Osmond)
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