Spurs or Dnipro will take on PAOK Salonika of Greece or last year's runners-up Benfica, who drop down from the Champions League, in the last 16.
Former UEFA Cup winners Valencia are to play Dynamo Kiev while Juventus, who surprisingly failed to make the Champions League last 16, could meet fellow Serie A side Fiorentina should they beat Turkish side Trabzonspor in the round of 32.
Napoli, who also failed to progress in the Champions League, will play Swansea City in the last 32.
(Reporting by Josh Reich; editing by Tony Jimenez)
