Pakistan have plenty of work to do to if they are to level their two-Test series with Sri Lanka in Abu Dhabi.
Having lost the first Test last week, the hosts saw Sri Lanka run up 482 on day two, before closing on 0-51 in response.
Dimuth Karunaratne's brilliant 196 was the mainstay of Sri Lanka's score, while 50s from Dinesh Chandimal, Niroshan Dickwella and Dilruwan Perera boosted the tally.
Yasir Shah took 6-184 to lead the way for Pakistan's bowling attack, his fifth five-wicket haul in as many Tests.
Shan Masood and Sami Aslam navigated 18 overs for Pakistan to give them some hope going into the third day.
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