It marked the fifth time in six meetings that Stephens has beaten fellow American Sands, all of the five other matches having been played on clay.
"I'm super excited to be back on hard courts again. I love running around out there," Stephens said after the match.
"I felt super comfortable, which was good," she said.
"Although the ball was coming really hard and she was crushing and rushing, I was ready."
The third ranked Stephens is the top remaining seed in the draw after world number two Caroline Wozniacki withdrew earlier on Tuesday with a right leg injury.
Elsewhere third-seeded Naomi Osaka won her debut match at the Citi Open with a 6-2 7-6(4) over American Bernarda Pera while eigth-seeded Donna Vekic broke Caroline Dolehide three times en route to a 6-3 6-4 victory.
Romanian Ana Bogdan stunned fourth seed Ekaterina Makarova 7-6(2) 6-3 and Kazakh Yulia Putintseva outlasted German Tatjana Maria 6-3 3-6 6-4.
(Reporting by Steve Keating in Toronto and Rory Carroll in Los Angeles; Editing by Ken Ferris/Amlan Chakraborty)
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