"Scans have revealed he suffered a ruptured cruciate ligament in his left knee and will have to undergo surgery," Stoke said on their website.
The Midlands club signed the one-cap Spain international forward from Barcelona on a four-year deal in July.
"It's bitterly disappointing for the club but even more so for Bojan himself as he was making such a big impact on the Premier League and clearly enjoying his football," said Stoke manager Mark Hughes. "We wish him a speedy recovery."
(Writing by Ken Ferris; Editing by Justin Palmer)
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