The 21-year-old Belgian, who also struggled for playing time after returning to United in January, has scored once in seven games in all competitions for Sunderland this season under manager David Moyes.
"Adnan Januzaj has been ruled out for a minimum of six weeks after suffering an ankle injury during Sunderland's 3-2 defeat to Crystal Palace," the club said in a statement.
Sunderland, who are at the bottom of the league table with one point from the opening six games, host West Bromwich Albion on Saturday.
(Reporting by Ian Rodricks in Bengaluru; editing by Amlan Chakraborty)
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