This is the second injury blow for the Champions League competitors after captain Simon Rolfes underwent ankle surgery last week and has been ruled out as well, with Leverkusen enjoying a fine start to the season.
The 18-year-old Brandt, an Under-19 Germany international, is among the country's brightest young talents and was on target in their 4-2 win over Hertha Berlin on Aug. 30.
Brandt turned his ankle in Monday afternoon's training but will not require surgery, Leverkusen said in a statement.
The German club, who lead the Bundesliga with two wins out of two games, kick off their Champions League matches against Monaco on Sept. 16 with Zenit St Petersburg and Benfica also in Group C of Europe's premier club competition.
(Reporting by Karolos Grohmann; editing by Sudipto Ganguly)
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