Older men treated with testosterone run a higher risk of death, heart attacks and strokes, according to a study suggesting the hormone therapy may need to be reconsidered.
The researchers followed more than 8700 men who had low levels of the hormone, of whom 1223 took a testosterone supplement for a median period of about two years.
Three years later, nearly one in five of the men who had not taken a supplement had suffered a heart attack or stroke, or had died.
That figure jumped to one in four among the group who had been treated with testosterone - an overall increased risk of almost 30 per cent.
The increased risk of catastrophic events was especially notable because "the men who were taking testosterone in this study were slightly healthier to begin with", said researcher Anne Cappola of the University of Pennsylvania.
The men receiving testosterone also tended to be younger - they had an average age of 61, compared to an average age of 64 for the untreated men.
"These findings raise concerns about the potential safety of testosterone therapy," the authors, including lead researcher Rebecca Vigan of the University of Texas, wrote in the study, published in the Journal of the American Medical Association on Tuesday.
They said further studies were needed "to properly characterise the potential risks", especially among older men or men with other risk factors.
The number of annual prescriptions for testosterone therapy increased five-fold between 2000 and 2011 in the United States, reaching 5.3 million prescriptions worth about $1.6 billion, the authors emphasised.
The therapy is recommended for those with below-normal levels of the hormone whose symptoms include diminished sex drive, low energy and worsening memory.
In addition to improving sex drive and bone density, the hormone has been shown to increase muscle mass and strength.
It is not clear from this research whether the increased risk of death, heart attack and stroke existed among patients prescribed testosterone therapy for "low T syndrome" or younger men taking it for physical enhancement, Cappola said.
An ongoing randomised trial of more than 800 men over the age of 65 receiving testosterone or a placebo could help provide guidance for older men considering testosterone therapy.
Until more is known, however, "prescribers and patients should be wary", she said.
Share
