Rafael Nadal's winning streak ended at 17 matches as he lost in straight sets to Dominic Thiem in the quarter-finals of the Italian Open.
The 6-4 6-3 victory was a sort of revenge for Thiem, who was beaten by the Spaniard in the Madrid Open final last week.
"Of course I came in with a very aggressive game style, because I knew that if I want to have a chance, then I have to do something different and be more aggressive," Thiem said.
"I knew that if it goes in, everything, maybe I have a chance. If not, maybe I also lose easy.
"But today was one of these days where I really felt the ball great on the racquet, and a lot of risky shots went in. It was a very, very good performance and I think probably one of my best matches."
The 30-year-old Nadal, who was seeded fourth, had won consecutive claycourt tournaments in Monte Carlo, Barcelona and Madrid and was aiming for an eighth title at the Foro Italico as he prepares for the French Open in less than two weeks.
"It's obvious that I did not play my best match. I have been playing a lot ... so is not easy after playing almost every day for the last four weeks," Nadal said.
Thiem, the No.8 seed, will face four-time champion Novak Djokovic or Juan Martin del Potro in the semi-finals.
Djokovic's match with Del Petro was suspended early in the second set because of rain.
At the time the players left the court the Serbian had won the first set 6-1.
He trailed 2-1 in the second set with the first three games going with serve.
Thiem, the 23-year-old Austrian, dominated from the start, racing into a 5-1 lead.
Nadal recovered and broke back to cut the gap to 5-4 but Thiem needed just one of his two set points when Nadal's backhand down the line landed just wide.
Thiem almost broke again early in the second set but Nadal managed to save two break points and go on to hold his serve.
However, Thiem took advantage on his opponent's next service game, putting in several delightful returns which had the audience on their feet before closing the game with a crosscourt forehand.
Thiem almost allowed Nadal back into the match but managed to cancel out three break points to go into a 5-3 lead and he broke again to take the match when Nadal sent a forehand long.
The other semi-final pits John Isner against No. 16 seed Alexander Zverev.
The unseeded Isner, who hit 21 aces, beat sixth-seeded Marin Cilic 7-6 (7-3) 2-6 7-6 (7-2) to become the first American to reach the last four at the Italian Open since Andy Roddick in 2008.
Zverev beat fifth seed and 2014 semi-finalist Milos Raonic 7-6 (7-1) 6-1.
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