Deschamps said that France captain Lloris had torn a muscle in his groin during the London club's 3-1 win over Real Madrid in the Champions League on Wednesday.
Lloris was therefore left out of the France squad to face Wales in a friendly on Nov. 10 at the Stade de France and against Germany in Cologne four days later.
The 30-year-old will also miss his club's Premier League fixture against Crystal Palace on Sunday.
(Reporting by Julien Pretot; Editing by Christian Radnedge)
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