The 26-year-old spent last season on loan with Southampton, making 26 Premier League appearances, and had been linked in media reports with a permanent move to St Mary's.
But the Belgium international will join countrymen Jan Vertonghen, Moussa Dembele and Nacer Chadli at White Hart Lane after joining Spurs for a fee reported in British media to be around 11.5 million pounds.
"I'm very proud to be a Tottenham player. I'm happy to be here and hope to have a wonderful time with this team," the club's twitter feed quoted him as saying.
(Reporting by Michael Hann; Editing by Amlan Chakraborty)
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