Victoria is heading towards its worst annual road toll in more than a decade with another five lives lost over the weekend.
Traffic police Assistant Commissioner Stephen Leane says the latest deaths add to an already "tragic start to the year".
On Monday, the road toll stood at 113 for 2019 or 39 more than the same period in 2018.
"If we continue to lose lives on our roads the way we are at this point of the year, there may be 300 souls lose their lives on Victorian roads this year," Mr Leane said.
"(It) is a terrible place to be considering that we had a record last year of 213, a record low."
The last time Victoria's annual toll exceeded 300 was 2008.
Three men died in three separate smashes on rural roads on Saturday.
The carnage began in the early hours of Saturday with two young men who'd been to a party decided to ride motorcycles home, one without lights on, Mr Leane said.
"Unfortunately, near the Midland Highway in Shepparton East, they collided with each other.
"One of those young men has lost their lives. So, they're never going to back to do the things that they hoped they'd do and have left family, friends and relatives behind."
A 16-year-old boy - named in media reports as Campbell Ion - died hours later in the state's south in a crash which also left his 18-year-old brother, Lucas, fighting for life.
They were driving to their game for Dalyston Football and Netball Club along the Bass Highway at Anderson, near Phillip Island, at 7.40am.
The impact on their family would be horrendous, Mr Leane said, not to mention the ripple effect that would affect their community.
The day's third tragedy happened about 12.30pm near Albury-Wodonga when a 58-year-old motorcyclist riding with a group crashed into a tree.
On Sunday afternoon a man and woman in their 20s died near Ballarat when they pulled onto the Glenelg Highway and into the path of a four-wheel drive towing a caravan.
"The caravan and the four-wheel drive had nowhere to go but to plough into them," Mr Leane said.
Of this year's toll, 72 people died on country roads - 30 more than in 2018 - and 24 were motorcyclists, which is nine higher than last year.
