Republican front-runner Donald Trump has swept to a commanding victory in Indiana, putting him on a glide path to the party's presidential nomination as Ted Cruz finally ended his campaign.
The New York billionaire won decisively in a state where Cruz, his nearest rival, had hoped to show he was still a factor in the race for the Republican nomination.
Republican National Committee chairman Reince Priebus called Trump the party's presumptive nominee in a tweet and said, "We all need to unite and focus" on defeating Clinton.
As the vote returns flowed in, Cruz announced that he has ended his campaign at an event in Indianapolis, with his wife, Heidi, at his side. Cruz, 45, sounding beaten but defiant, said he no longer sees a viable path to the nomination.
"Together we left it all on the field in Indiana," said Cruz, a US senator from Texas. "We gave it everything we got. But the voters chose another path, and so with a heavy heart, but with boundless optimism for the long-term future of our nation, we are suspending our campaign."
Trump was on track to take over 50 per cent of the vote. Ohio Governor John Kasich was running a distant third.
On the Democratic side, Bernie Sanders won the presidential primary with 53 per cent of the vote compared with 47 per cent for Hillary Clinton, with 64 per cent of precincts counted.
But it's a win that won't change the reality of the Democratic race.
The Vermont senator is far behind the former secretary of state in the delegate count. Clinton entered the night with 91 per cent of the delegates she needs to become the first woman nominated by a major party.
Cruz had been counting on a win in Tuesday's primary to slow the New York businessman's progress towards the nomination. But Trump rode momentum from wins in five northeastern states a week ago to wrest Indiana from Cruz, whose brand of Christian conservatism had been expected to have wide appeal in the state.
David Yepsen, director of the Paul Simon Public Policy Institute at Southern Illinois University, said the Republican race is over.
"Cruz is certainly young enough to fight again another day. Kasich's a serious guy but if stays in this he could look silly," Yepsen said.
The loss for Cruz was a sour ending to a rough day in which he got entangled in a harsh back-and-forth with Trump.
It began when the billionaire repeated a claim published by tabloid newspaper the National Enquirer that linked Cruz's father, Cuban emigre Rafael Cruz, with President John F Kennedy.
Kennedy's assassin Lee Harvey Oswald.
Campaigning in Evansville, in the state's southwest corner, Cruz sounded deeply frustrated by the bombastic real estate mogul, who has ripped Cruz at every turn.
"The man cannot tell the truth but he combines it with being a narcissist," Cruz said, "a narcissist at a level I don't think this country has ever seen."
Cruz termed Trump a "serial philanderer" - likely as part of his strategy to try to win the support of evangelical voters.
Trump, in response, said Cruz had become "more and more unhinged".
The only hope Kasich has for becoming the Republican nominee is to somehow deny Trump the 1237 delegates he needs to win the nomination outright and force Republicans at their July convention in Cleveland to choose one of them.
Kasich vowed to stay in the race.
"Tonight's results are not going to alter Governor Kasich's campaign plans," Kasich senior strategist John Weaver said in a campaign memo. "Our strategy has been and continues to be one that involves winning the nomination at an open convention."
A 'tremendous victory'
Trump called Indiana a "tremendous victory" and immediately directed fire at Clinton.
"We're going after Hillary Clinton," he said. "She will not be a great president, she will not be a good president, she will be a poor president. She doesn't understand trade."
He declared Cruz was a tough man to beat.
"Ted Cruz, I don't know if he likes me or doesn't like me. But he is one hell of a competitor. He is one smart guy. And he has got an amazing future," Trump said.
Trump also reached out to both Hispanics and African-Americans as he talked about ensuring jobs and saying he would "make America great again."
"This is going to be a beautiful and loving country," Trump said.
Republican National Committee Chairman Reince Priebus called Trump the party's presumptive nominee in a tweet and said, "We all need to unite and focus" on defeating Clinton.
Anti-Trump groups vow to continue fighting
But anti-Trump groups said they would continue fighting, and Lanhee Chen, who had advised former Republican candidate Marco Rubio, broached the possibility of a third-party candidate.
"Tonight's outcome raises seriousness & urgency of discussions about third-party alternative; how real it is depends on who steps up to run," he tweeted.
Cruz had been counting on a win in Tuesday's primary to slow the New York businessman's progress toward the nomination. But Trump rode momentum from wins in five Northeastern states a week ago to wrest Indiana from Cruz, whose brand of Christian conservatism had been expected to have wide appeal in the state.
The only hope Kasich has for becoming the Republican nominee is to somehow deny Trump the 1,237 delegates he needs to win the nomination outright and force Republicans at the July convention to choose one of them.
Kasich vowed to stay in the race.
"As long as it remains possible Governor Kasich will fight for the higher path," said Kasich senior strategist John Weaver. "Governor Kasich will continue to campaign and offer the voters a clear choice for our country."
