Malcolm Turnbull has hit out at those who accused him of pursuing a "vanity project" ahead of the Trans-Pacific Partnership free trade pact's signing in Chile.
The deal had been on life support after the United States' withdrawal, but was resuscitated in January following lobbying from Japan and Australia.
Trade Minister Steve Ciobo will join his counterparts from 10 Pacific countries for the signing ceremony on Friday 5am (AEDT).
The prime minister described the event as a historic achievement and a jobs booster, and recalled how Opposition Leader Bill Shorten had proclaimed the deal was dead after Donald Trump pulled the plug on America's involvement.
"He (Mr Shorten) accused me of being on a vanity project and wasting my time. I kept going with it," Mr Turnbull said.
"(It's) a huge demonstration of our relentless commitment to getting every export opportunity made available for Australian businesses."
The deal will eliminate 98 per cent of tariffs in a marketplace worth close to $14 trillion.
Mr Ciobo said Aussie farmers, manufacturers, service providers and small businesses would be the big winners.
"The more Australian products and expertise sold to the world, the more Australian jobs created," he said.
"It sends an important message to the world that prosperity is achieved through breaking down trade barriers not building them."
The TPP deal covers Australia, Brunei, Canada, Chile, Japan, Malaysia, Mexico, New Zealand, Peru, Singapore and Vietnam.
Australian exporters will get better access for dairy products and sugar into Japan, Canada and Mexico and all tariffs on sheepmeat, cotton, wool, seafood, horticulture and wine will be eliminated.
Mr Ciobo expects the controversial US tariffs saga to be discussed on the sidelines of the Chile signing ceremony.
Australia is among the countries trying to dodge the Trump administration's proposed 25 per cent tariff on steel and 10 per cent tariff on aluminium imports.
The White House has opened up some wriggle room on possible country exemptions on a case-by-case basis.
Mr Trump is expected to sign a presidential proclamation setting up the tariffs at 7.30am on Friday (AEDT), with the measures taking effect two weeks later.
Labor trade spokesman Jason Clare said America had no closer ally or friend than Australia.
"If it is good enough for Canada and for Mexico to get an exemption from these tariffs then we should get an exemption as well," Mr Clare told reporters in Sydney.
