"I think it's no surprise for anyone after three years in the Premier League, playing every week, so everyone knows what Alexis is," Mourinho told the club's website (www.manutd.com).
"He is the kind of player you buy and you don't think about adaptation in relation to English football, so it's no surprise for us," the Portuguese manager added.
"He is a fantastic player and he showed that for three years and for the past three days when he was training for us, so he's an amazing addition for us."
Forward Marcus Rashford and midfielder Ander Herrera both struck either side of halftime, while Jesse Lingard and Romelu Lukaku scored late on to complete the rout.
Sanchez, who last played in Arsenal's goalless League Cup semi-final first leg draw with Chelsea earlier this month, was taken off after 72 minutes against Yeovil.
"He didn't play for Arsenal the last two or three games and his training was not good because half of his body was in the Emirates and half in Manchester, so you don't train well," Mourinho said.
"I was not sure about 90 minutes, I wanted to play him for 60, 70 or 75 and that was good because people understand his game better and he can understand his team-mates too."
The 12-times FA Cup champions will discover their fifth round opponents when the draw is made on Monday. They then return to Premier League action at Tottenham Hotspur.
(Reporting by Shrivathsa Sridhar in Bengaluru; editing by Amlan Chakraborty)
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