Cristian Rodriguez, 32, and Carlos Sanchez, 33, have been named in the starting line-up with wingers Giorgian De Arrascaeta, 24, and Nahitan Nandez, 22, sliding to the substitutes' bench.
Uruguay will qualify for the last-16 if they beat Saudi Arabia, a result that would also send hosts Russia through.
(Reporting by Julien Pretot, additional reporting by Alexandra Ulmer and Richard Martin; Editing by Christian Radnedge)
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