Germany is known for its powerful attack and this year Loew will have veteran Miroslav Klose, Lukas Podolski of Arsenal and Thomas Mueller of Bayern Munich fame.
Indeed, Die Mannschaft has plenty of talent all around the park, with the likes of Sami Khedira, Mesut Ozil, Manuel Neuer, Marco Reus, Andre Schuerrle, Toni Kroos and Mario Goetze to contend with.
Schuerrle, who plays in England with Chelsea, says victory in Germany's first-up clash with Portugal will be integral.
"It's going to be very difficult and you know you have to be on the top in the first game against Portugal because maybe it's the best team with us in this group."
"You have to be on the top level in the first match, so I don't know. We'll have to wait and see if we can be on the top level and then to keep going to the final."
Portugal will be led by the talismanic Real Madrid star Cristiano Ronaldo.
Going into his third World Cup, the 29-year-old insists cool heads will help Portugal progress from the group stages.
"We aren't the favourites, so it is good because we don't have so much pressure on us; that will come later. We will try to enjoy it. We have a very difficult group stage, in my opinion the toughest in the world cup, but we'll take it one step at a time"
However, an ever-improving USA will be all too happy to cause an upset.
German coach Jurgen Klinsmann has made goalkeeper Tim Howard, strikers Clint Dempsey and Jozy Altidore and midfielders Michael Bradley and Jermaine Jones the spine of his squad.
Meanwhile, Ghana will rely on skipper Asamoah Gyan and Michael Essien for experience and stability
Emerging striker Abdul Majeed Waris of Valenciennes in France and Christian Atsu of Vitesse in the Netherlands will provide energy around the park.
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