An election-year fight over addressing the spreading Zika virus has intensified in the US Congress as the Senate approved $US1.1 billion ($A1.52 billion) in emergency money one day after the House of Representatives voted $US622.1 million financed through cuts to existing programs.
The two chambers would have to reach agreement on a spending level before they can send it to President Barack Obama, who in February requested $US1.9 billion.
The White House has called the House measure "woefully inadequate".
The Senate goes into the negotiations with the House with a strong hand: a bipartisan 68-30 vote in favour of the emergency funds to battle Zika, a virus that has been spreading rapidly through the Americas, with more than 100 confirmed cases in the US state of Florida.
US health officials have concluded that Zika infections in pregnant women can cause microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies.
The World Health Organisation has said there is strong scientific consensus that Zika can also cause Guillain-Barre, a rare neurological syndrome that causes temporary paralysis in adults.
Conservative Republican Senator Mike Lee of Utah tried unsuccessfully to kill the Senate funding on Thursday, saying the Obama administration already had enough money to deal with Zika.
"What we should not do, however, is allow the Zika virus to be yet another excuse to run up the national debt," Lee said.
But Senator Susan Collins of Maine, a moderate Republican, countered that US debt problems were rooted in the rapid growth in the cost of huge programs such as Social Security and Medicare and not so-called "discretionary" spending like on Zika.
"If ever there were an emergency, it is the threat posed to public health by the Zika virus," Collins said, adding that health experts she has met with made her conclude that on Zika's impact, "The news keeps getting worse and worse."
The Zika measure in the Senate was attached to an unrelated transportation and housing appropriations bill that still must be approved by the Republican-controlled chamber.
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