Real Madrid passed up the chance to move further clear at the top of La Liga as two early goals saw them slip to defeat at Valencia.
Zinedine Zidane's side had two games in hand on second-placed Barcelona heading into their clash at the Mestalla, but remain just one point clear having been beaten 2-1 in just their second league loss of the season.
Simone Zaza and Fabian Orellana struck inside the opening 10 minutes for struggling Valencia, who notched up just their seventh league win of the campaign as the visitors could not add to Cristiano Ronaldo's header on the stroke of half-time.
"We lost this game in 10 minutes. We made two mistakes and they scored twice," Madrid coach Zinedine Zidane said. "We tried to get back into the game but we were missing a lot of things today. We had the chance to add some points but couldn't do it."
Juventus loanee Zaza opened the scoring in style as he turned and volleyed Munir El Haddadi's cross past the diving Keylor Navas.
Toni Kroos saw a shot blocked as Real looked to respond immediately, but instead the league leaders found themselves further behind moments later.
The hosts countered at speed and Orellana slotted home between Navas' legs to double their advantage with only nine minutes on the clock.
Both Karim Benzema and Ronaldo saw shots well saved by Diego Alves before the latter marked the 700th club appearance of his career by rising to head home Marcelo's cross just before the interval.
Having won 16 of their previous 21 league outings, a second-half comeback would have been expected.
But it did not come despite the best efforts of Zidane's players and the introduction of Gareth Bale off the bench as the game wore on.
Marcelo fired wide and Kroos had an effort blocked as Daniel Parejo and Zaza kept the Madrid defence honest at the other end.
"We got off to a slow start. There is no excuse for that. We are the ones to blame," Marcelo said. "We have to learn from our mistakes and make sure that this doesn't happen again."
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