The Catalans are 11 points clear at the top of the table with six matches remaining, but face Sevilla in the King's Cup final on Saturday at the Wanda Metropolitano in Madrid.
Barcelona are unbeaten in a league record 39 games but will risk that streak ending as they head to Vigo with a weakened squad, which the club named Monday.
Last season Barcelona were beaten 4-3 at Celta in the league and suffered a 4-1 humiliation the year before that.
Lucas Digne returns to the squad after injury, while Aleix Vidal and Yerry Mina have been recalled after being omitted for the 2-1 win over Valencia in La Liga on Saturday.
(Reporting by Rik Sharma; Editing by Ken Ferris)
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