The Dutchwoman, who wrapped up her Tour of Italy title on Sunday, still had the strongest legs as she chased down Olympic champion and compatriot Anna van der Breggen after being dropped in the last climb up the Col de la Colombiere.
Mitchelton Scott rider Van Vleuten reined in Van der Breggen on the final descent and won the two-woman sprint.
“It was unbelievable. With 300 metres to go I still thought I would get second and then I saw her dying. To win like this...it was a tough ride, but beautiful`,” Van Vleuten said.
“The gap going into the descent was really small and Anna is also a really good descender, but I always keep believing and keep on thinking that anything is possible and never give up. That was really important today.
“This win is really beautiful, the second time at La Course and especially coming only two days after winning the Giro Rosa, but to win this race in this way is really special and high up on my list of memorable wins.”
South African Ashleigh Moolman, second overall in the July 6-15 Giro Rosa, took third place, one minute 22 seconds off the pace.
(Reporting by Julien Pretot, editing by Ed Osmond)
