Victoria is facing its most severe fire danger so far this summer, with temperatures forecast to soar into the high 30s in the coming days.
Total fire bans are in place in every region except East Gippsland on Friday, then covering the whole state on Saturday.
"It's extremely dry. Victoria's almost in a sub semi-drought in some parts," Emergency Management Commissioner Craig Lapsley told reporters.
As firefighters prepare for the worst, paramedics are urging people to check on family and friends, particularly those over 65.
"Try to stay inside, use cooling if you have it, and drink plenty of water unless your doctor has restricted your fluid intake," Ambulance Victoria State Health Commander Paul Holman said.
Temperatures are tipped to stay as high as 28c overnight, before hitting 39c in Melbourne and more than 40c in regional areas on Saturday.
Ambulance Victoria's Paul Holman said the overnight heat would mean ill and elderly people could struggle on Saturday.
"The body doesn't have enough time to recover," he said.
Mr Holman said people should check on their neighbours and make sure they stay hydrated and out of the heat if possible.
"Some of the interesting research out recently has shown that slushies, or ice drinks, are very effective in cooling. So that's probably a good tip for people - use slushies," he said.
Premier Daniel Andrews told parents not to leave children in cars, and to report anyone lighting fires.
"Today is about making sure we do nothing to contribute to a fire," he said.
Victoria Police acting commissioner Tim Cartwright urged people to call 000 if they see anyone lighting a fire or welding or using an angle grinder.
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