United went ahead after 32 minutes when 18-year-old Marcus Rashford found room in the box before picking his spot past Villa keeper Brad Guzan for his seventh goal of the season.
England captain Wayne Rooney made his first appearance in the league since mid-February after fully recovering from a knee injury before being replaced by Jesse Lingaard after 67 minutes.
(Reporting by Mike Collett; Editing by Toby Davis)
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