"After speaking to consultants and seeking specialist opinion, the decision has been taken in Dan's best interests to undergo surgery," Ospreys medical performance manager Chris Towers said.
"That process will take place this week, ruling him out of consideration for the rest of the current season."
Wales are already without flanker Sam Warburton and centre Jonathan Davies for the Feb. 3 to March 17 Six Nations, while number eight Taulupe Faletau is also a doubt due to a knee injury.
Warren Gatland's side kick off their campaign against Scotland in Cardiff on Feb. 3.
(Reporting by Aditi Prakash in Bengaluru; Editing by Peter Rutherford)
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