Warrington put a dampener on Kevin Sinfield's 500th appearance for Leeds as they completed a notable double over the Super League leaders in emphatic fashion at Headingley.
Sinfield was on the losing side on his debut for the Rhinos against Sheffield Eagles at Headingley in 1997 and he was powerless to prevent a repeat on his landmark occasion, with the Wolves running out 29-10 winners.
The Rhinos were already trailing 20-4 when the former England skipper entered the action five minutes into the second half and it did not get much better as the Yorkshiremen came up with their worst performance of the season in front of a 17,430 crowd.
Huddersfield gained sweet revenge for their opening-round defeat by Hull FC with a 24-4 victory at the KC Stadium which moved them to fourth on the table.
The Giants were kept scoreless in the reverse fixture at the John Smith's Stadium as Hull claimed a surprise 19-0 win and they appeared determined to right those wrongs in a dominant first-half display.
Tommy Makinson took the honours as St Helens ended their dismal run of only one victory in their previous five Super League matches with a 34-16 triumph at home to Widnes.
Fullback Makinson scored a spectacular long-range try to seal the win eight minutes from time and also set up another touchdown for youngster Matty Fleming.
Luke Walsh, making his first start of the season after breaking his leg last July, had only made two substitute appearances recently but also showed what Saints have been missing with a top show.
The 27-year-old former Penrith halfback scored a try and helped create two others for Travis Burns and Alex Walmsley.
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