The fifth seed had complained about his punishing schedule before the match but was efficiency itself as he won the pivotal points to snatch the first two sets on tiebreaks on the bowl-like Court Two.
Spanish left-hander Lopez, a regular in the second week of Wimbledon, lost seemed to lose composure in the third set as Wawrinka moved into his first Wimbledon quarter-final.
The 29-year-old's clash with Davis Cup team mate Federer will be his third match in three days after his progress was clogged by weekend rain that made a mess of the schedule.
(Editing by Martyn herman)
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