Plus Australia takes on England looking to repeat a famous victory from 2003.
Those matches plus all the NRL, AFL and Formula One action headline what's set to be a busy weekend of sport.
For the second time in three years the UEFA Champions League final has become a private battle between Mardid's two biggest clubs, Real and Atletico.
The fans of both sides will fill Milan's San Siro Stadium on Sunday.
Real's superstar forward Ronaldo sent shockwaves of concern through his camp when he limped out of training during the week.
But the 31-year-old Ronaldo, wo scored in the final two years ago as Real won 4-1 assured fans it was more of a precaution than anything serious.
"I feel good. I just had a small problem in the training today, but in a couple of days I will be 100 per cent."
Atletico were considered unfortunate to have lost so heavily in the final two years ago, as Real only equalised deep into added time before scoring three more times, in extra time.
Despite that win, Real never enjoys playing its bitter rival, least of all in a match when the sides know each other so well.
Welsh international Gareth Bale has scored 33 times in all competitions this season for Real.
He says he's expecting a tough match.
"I think like any other game against Atletico. We know it's going to be a difficult game, they are going to defend very well but we have to be patient and hopefully we can break them down and score goals."
Atletico will be looking to win its first Champions League title and stop Real being crowned Kings of Europe for an 11th time.
The match will be on SBS on Sunday morning from 4.15 in the Eastern States.
In the early hours of Saturday morning, the Socceroos will be looking to dent England's confidence going into the Euro tournament in France by handing Australia's oldest sporting enemy a rare home defeat.
That's exactly what Australia did thirteen years ago at Upton Park in a three-one victory.
England goes into the match full of confidence after winning all its Euro qualifiers.
But Australia's goal-keeper, Mat Ryan, believes beating England is no longer an end in itself.
"The ultimate goal one day is to win a World Cup and we have to come to foreign soil and play a team like England and I'm confident we can come up with a game plan to do the job."
In AFL action tonight on Friday, the Sydney Swans will look to inflict the first defeat of the season on the North Melbourne Kangaroos at the SCG.
This is despite having nine wins to their name already.
Six of those Kangaroos victories have come on home soil.
Richmond goes into its clash with Essendon on Saturday at the MCG looking for its fourth win of the season against the Bombers, who have won just once.
The Tigers though, have given Chris Yarran indefinite leave to deal with a mental health condition.
Coach Damien Hardwick says Yarran, who's not played for the Tigers since moving from Carlton, will be given all the time he needs to get back to his best.
"It's a medical condition. It's a private matter so there's not a lot I can elaborate on. Look Chris' health and wellbeing is of the utmost important thing to us. And there's no timeframe on his return at this stage so from our point of view he's a great young player and we wish him all the best.
Because of next week's State of Origin there's a truncated NRL round this weekend, with just four instead of the usual eight fixtures.
Perhaps the pick of those matches is Sunday's clash between the seventh placed Raiders and the fifth placed Bulldogs.
Meanwhile, there's an international flavour to the Super Rugby on Saturday night when the Brumbies welcome Japanese outfit the Sunwolves to Canberra.
In Motorsports this weekend, the Formula One Grand Prix at Monaco will dominate the headlines.
The ongoing feud between Mercedes drivers Nico Rosberg and Lewis Hamilton will be one of the focal points.
British driver Hamilton and German Rosberg collided in Barcelona last weekend in an accident that race stewards ruled was a "racing incident".
Both men say the incident is now behind them.
But Rosberg suggested the will to get one over his rival is just as strong as before.
"Nothing's changed. Now, going out on track, I'm not going to be thinking about Barcelona. I'll take the same approach as always - flat out and do what's necessary to try to win this grand prix, which is what I've come here to do."
Rosberg leads the standings on 100 points ahead of Ferrari's Kimi Raikkonen with Hamilton back in third.
And in netball action, the top two teams in the Trans Tasman Championship will go head to head when the Queensland Firebirds travel to Sydney to take on the second placed Swifts.
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