The highly-contagious tropical bug has infected hundreds of people in Guinea, Liberia and Sierra Leone, with the latest World Health Organization (WHO) figures showing confirmed or suspected cases had left 467 people dead.
The new toll represented a rise of 129 - or 38 per cent - since the UN agency's last bulletin a week ago.
"These kinds of outbreaks, these diseases, can be stopped," Keiji Fukuda, assistant director-general for health security at the WHO, told AFP, as 11 west African health ministers gathered for a two-day conference in Accra.
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"This is not a unique situation - we have faced it many times - so I'm quite confident that we can handle this.
"This is, however, the most complicated Ebola outbreak ever because it is spreading so fast in both urban and rural areas."
Despite the efforts of the UN agency and other health workers, there has been a "significant increase" in the rate of new cases and deaths in recent weeks, the organisation added.
Ministers from Guinea, where 413 confirmed, suspected and probable cases have surfaced so far including 303 deaths, and Liberia, which has seen 107 cases and 65 deaths, are at the meeting.
Sierra Leone, which has recorded 239 cases and 99 deaths, is also represented.
In addition, officials from Ivory Coast, Mali, Senegal, Gambia and Guinea-Bissau, along with Ghana and countries as far afield as Uganda and the Democratic Republic of Congo are attending.
They have been joined by a host of UN agencies and other aid organisations, as well as personnel from disease control centres in western Africa, the United States, Britain and the European Union.
