"A scan on Tuesday revealed that the injury will keep him out of contention for up to six weeks," the London club said on its website (www.whufc.com).
The 26-year-old Sakho will join winger Gokhan Tore and defenders Sam Byram, Arthur Masuaku and Reece Oxford on the treatment table at West Ham.
The Hammers will be at Old Trafford again on Wednesday to face United in the League Cup quarter-finals before taking on Arsenal at home in the Premier League this weekend.
(Reporting by Shravanth Vijayakumar in Bengaluru; editing by Ken Ferris)
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