Captain Denesh Ramdin is hoping to put the South Africans under pressure with a misfiring opening partnership and new players at six and seven in the home line-up.
The tourists have selected the fastest bowler in their squad, Shannon Gabriel, for the injured Kemar Roach, while left-arm seamer Kenroy Peters, 32, makes his debut.
Medium-pacer Jason Holder, recently installed as new one-day international captain, also comes in, with batsman Jermaine Blackwood and fast bowler Sheldon Cottrell the two players missing out.
South Africa have handed a debut to 24-year-old right-hander Temba Bavuma, replacing the injured wicketkeeper Quinton de Kock and likely bat at seven with AB de Villiers taking the gloves.
The home side have also brought in leg-spinner Imran Tahir in the place of seamer Kyle Abbott on a pitch that has traditionally been spin-friendly.
South Africa won the first test in the three-match series by an innings and 220 runs in Pretoria.
Teams:
South Africa: Alviro Petersen, Dean Elgar, Faf du Plessis, Hashim Amla (captain), AB de Villiers, Stiaan van Zyl, Temba Bavuma, Vernon Philander, Dale Steyn, Morne Morkel, Imran Tahir
West Indies: Devon Smith, Kraigg Brathwaite, Leon Johnson, Marlon Samuels, Shivnarine Chanderpaul, Denesh Ramdin (captain), Jason Holder, Jerome Taylor, Sulieman Benn, Shannon Gabriel, Kenroy Peters
(Reporting by Nick Said; Editing by John O'Brien)
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