Rain and possible thunderstorms have been forecast for the Emilia-Romagna region from 1900 local time (1700GMT), with Mitchelton-Scott rider Yates scheduled to start the 8km race against the clock at 1943.
Yates reckons he is favourite to win the three-week race but faces competition from other top riders, such as Dutchman Tom Dumoulin -- the first to start -- Slovenian Primoz Roglic and Italian Vincenzo Nibali who will depart at 1701 at the latest.
Yates, however, prefers to know his rivals' times before the trial, which ends with a punishing 2-km climb up to San Luca.
"Saturday's weather is just a prediction,. Nobody knows what it will be like," the Vuelta champion said with a shrug.
"I normally want to know my opponents' times and work around that. So I stick to the plan and start last from my team."
Yates has unfinished business with the Giro after a spectacular collapse in the 19th stage last year, when he was wearing the race leader's Maglia Rosa, saw him drop out of contention.
"I've dedicated the last 12 months to this race now. I know that time trials will make my task very difficult against the likes of Dumoulin and Roglic but I won the last time trial I did (at Paris-Nice in March)," the Briton said.
Asked who was favourite to win the race, which finishes in Verona on June 2, Yates replied: "Me".
(Reporting by Julien Pretot; Editing by Ken Ferris)
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