"Lejeune has been ruled out for the remainder of the current season and further updates on his recovery will be provided in due course," Newcastle said on their website.
Lejeune, 27, missed the start of the campaign after sustaining a right knee injury in pre-season but has featured 13 times in all competitions since returning in January.
Newcastle are 15th in the league standings with 35 points from 33 matches.
(Reporting by Shrivathsa Sridhar in Bengaluru; Editing by Christian Radnedge)
