Bacteria linked to stillbirth: mouse study

A mouse study has found a link between a common bacteria, called group B Streptococcus, and preterm and stillbirths.

A common bacteria about a third of women carry has been linked to premature delivery and stillbirths in a study using mice.

Group B Streptococcus (GBS) bacteria can be found in the vagina of 20 to 30 per cent of all women and is regularly tested for in late pregnancy.

It's known the bacteria can cause a baby to develop a serious infection, like meningitis or pneumonia, if a woman who carries the bug is not treated with anitbiotics - usually penicillin.

There is about a 1 in 200 chance of that happening, according to infectious diseases expert Professor Sanjaya Senanayake from the Australian National University (ANU).

There has been, however, some conjecture whether GBS could cause problems before delivery, such as stillbirths and premature delivery.

But a study conducted by researchers at the Indian Institute of Technology - Bombay, published in the journal PLOS Pathogens, has found a link.

When doctors look at a placenta under a microscope after a stillbirth they will see inflammation but they won't always find the cause, says Prof Senanayake.

"What these scientists are saying is that they found the bug, that can cause problems in newborns, can produce these little packets of inflammation and without moving from the vagina can send these packets of inflammation into the womb and can cause induced premature labour and stillbirths," Prof Senanayake said.

He said that would explain why in some cases of stillbirths and premature babies inflammation could be seen under the microscope but the bacteria could not.

According to the study, 60 per cent of fetuses were born prematurely - by day 18 of pregnancy - after the scientists directly injected the amniotic sac in the pregnant mice with the bacteria.

An increased frequency of fetal death in utero was also observed.

Prof Senanayake says the finding could potentially have implications for the management of GBS during pregnancy.

"Does that mean then we start doing swabs earlier in pregnancy to see if it's there?

"And if it is there maybe giving antibiotics to try and get rid of it," said Prof Senanayake.

However, it was too early to suggest a definitive link had been found despite mice being gentically similar to humans, he warned.


Share
3 min read

Published

Updated

Source: AAP

Share this with family and friends


Get SBS News daily and direct to your Inbox

Sign up now for the latest news from Australia and around the world direct to your inbox.

By subscribing, you agree to SBS’s terms of service and privacy policy including receiving email updates from SBS.

Download our apps
SBS News
SBS Audio
SBS On Demand

Listen to our podcasts
An overview of the day's top stories from SBS News
Interviews and feature reports from SBS News
Your daily ten minute finance and business news wrap with SBS Finance Editor Ricardo Gonçalves.
A daily five minute news wrap for English learners and people with disability
Get the latest with our News podcasts on your favourite podcast apps.

Watch on SBS
SBS World News

SBS World News

Take a global view with Australia's most comprehensive world news service
Watch the latest news videos from Australia and across the world