Missing Melbourne mum Elisa Curry only has a "very remote" chance of being alive in the bush along Victoria's Great Ocean Road, police say.
The 42-year-old went missing from her Aireys Inlet holiday home on Saturday night or Sunday morning, while her husband and children were returning from Melbourne.
Ms Curry is an avid marathon runner and has been known to run to Lorne - 20km away - via bush tracks.
"Unfortunately the best medical advice is that if she is in the bush, that the chances of her being alive are very remote," Inspector Peter Seel told Seven Network on Thursday.
Police have searched the bush tracks Ms Curry was known to run along, as well as investigating any potential suspicious circumstances.
Distraught husband David Curry has pleaded with Ms Curry to come home.
"As you'd expect he's very upset. He's really concerned about his children's welfare and of course his wife's, but he's trying to hold up as best he can for the children," Insp Seel said.
Ms Curry sent a text message to the Herald Sun on Saturday afternoon, supporting John Howard's view that the details of proposed same-sex marriage legislation should be known, but Insp Seel said it was not relevant to the case.
"No, completely unrelated, that text message was sent about 2.40pm on the Saturday afternoon, so no relation at all," he said.
A local woman, who did not want to be named, said Aireys Inlet is a tight knit community and the situation has left residents unsettled.
"Everyone knows everyone and if they keep to themselves, you recognise them," she told AAP.
"It's spooky."
Police have narrowed their search to an area of about 150 metres around Ms Curry's home, and they are doorknocking the area and searching backyards and sheds.
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