Unveiled today, the piece was created by Jenna Lee, an artist from Indigenous design agency Gilimbaa, in collaboration with Murri Elders.
Named The Pulse of Our Ancient Land, it depicts the landscape passengers see as they touch down in Brisbane, brought to life through glass, watercolour and moving lights.
"The first time we met with the elders, we said, 'what do you want people to know?'. And they said, 'our land is alive and when you fly over it, it's pulsating and it has beauty', and that really summarises the artwork," says Ms Lee.
"(It's) specific to this place, in terms of Aboriginal people, and the stories that our elders wanted travelers to know."
The stories behind the piece are explained in a description beside the artwork, in English and in language.
It's hoped the prominently-placed art will encourage overseas visitors to learn more about Aboriginal and Torres Strait Islander culture.
"It’s important for us that we reflect the heritage of our history, and the history of Australia as well, so having that art installation in the entranceway into this land is very, very important for us," says Qantas International CEO Gareth Evans.
"It’ll be great for all our Australian guests, our Queensland guests and our international guests as well... to be able to look at it and interact with it, and learn a bit more about the heritage of this part of the world."