Actress and screenwriter Emma Thompson said in an interview with the BBC that there would have been many opportunities to call Weinstein out on his alleged sexual harassment.
The Oscar-winning actress - who said she never worked with Weinstein as a producer - also weighed in on the numerous allegations thrown at him by numerous people in the entertainment industry.
''You know this man is at the top of a very particular iceberg, I don't think you can describe him as a sex addict, he's a predator, that's different," she said.
"But what he's, as it were, at the top of the ladder of a system of harassment and belittling and bullying and interference and what my mother would have referred to in the olden days as pestering - 'is he pestering you?"
Harvey Weinstein attends a pre BAFTA party in London. Source: SBS
Ms Thompson said it was up to people to not turn a 'blind eye' from the system and to speak out, to help the women at the centre of the ordeal.
The actress predicted that there would have been "missed opportunities" to call Weinstein out on his alleged offences.
''I think there are probably about a million missed opportunities to call this man out on his disgusting behaviour," she said.
Weinstein has previously denied having non-consensual sex with anyone.
His team did not respond to an emailed request from Reuters for comment related to Thompson's interview.
Sophie Dix speaks out
A British actress who starred alongside Colin Firth in a film in the early 1990s has accused Harvey Weinstein of sexual assault and says the incident "massively cut short" her career.
Sophie Dix, 48, has told the Guardian Weinstein pushed her on to the bed of his room at London's Savoy hotel in 1990 and began tugging at her clothes after he invited her to his room to help him make a decision about another movie.
This is the latest in a string of sexual harassment allegations against the movie mogul, who has been accused of rape by three women - claims Weinstein "unequivocally denies".
Dix was 22 at the time of the alleged sexual assault and says she thought about reporting it to police but feared it would damage her career.
She said Weinstein invited her to dinner in Covent Garden after she was cast alongside Firth in the film The Hour Of The Pig, which was named The Advocate in the US.
"It was an exciting time of my life. I was open and trusting and I had never met a predator; I had never considered a predator," Dix told the Guardian.
She said Weinstein "made sure the wine was flowing" before asking her to come to his room to help him make some decisions over another film.
"As soon as I was in there, I realised it was a terrible mistake. I got to the hotel room, I remember talk of a massage and I thought that was pretty gross. I think he showed me his big back and I found that pretty horrid.
"Then before I knew it, he started trying to pull my clothes off and pin me down and I just kept saying 'no, no, no'. But he was really forceful. I remember him pulling at my trousers and stuff and looming over me."
Dix escaped to the bathroom where she locked the door.
"After a while I remember opening the door and seeing him just there facing the door masturbating, so I quickly closed the door again and locked it. Then when I heard room service come to the door I just ran."
Dix, who has worked on different TV shows and now works as a screenwriter, claims she was "very, very vocal" about it at the time, but those in the industry "didn't want to know about it".